Structure, Activity Regulation, and Role of the Mitochondrial Calcium Uniporter in Health and Disease

Mitochondrial Ca2+ uptake plays a pivotal role both in cell energy balance and in cell fate determination. Studies on the role of mitochondrial Ca2+ signaling in pathophysiology have been favored by the identification of the genes encoding the mitochondrial calcium uniporter (MCU) and its regulatory...

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Bibliographic Details
Main Authors: Cristina Mammucari, Gaia Gherardi, Rosario Rizzuto
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-07-01
Series:Frontiers in Oncology
Subjects:
Online Access:http://journal.frontiersin.org/article/10.3389/fonc.2017.00139/full