Functional polymorphism of the renalase gene is associated with cardiac hypertrophy in female patients with aortic stenosis.

Renalase decreases circulating catecholamines concentration and is important in maintaining primary cellular metabolism. Renalase acts through the plasma membrane calcium ATPase 4b in the heart, which affects pressure overload but not exercise induced heart hypertrophy. The aim of this study was to...

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Main Authors: Ewa Orlowska-Baranowska, Lucja Gadomska Vel Betka, Jaroslaw Gora, Rafal Baranowski, Ewa Pedzich-Placha, Dariusz Zakrzewski, Angelika Dlugosz, Helena Kossowska, Agnieszka Zebrowska, Ewelina Zakoscielna, Anna Janiszewska, Tomasz Hryniewiecki, Zbigniew Gaciong, Grzegorz Placha
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5655536?pdf=render