Metabolic modelling reveals broad changes in gut microbial metabolism in inflammatory bowel disease patients with dysbiosis

Abstract Inflammatory bowel diseases, such as Crohn’s Disease, are characterised by an altered blood and faecal metabolome, and changes in gut microbiome composition. Here, we present an efficient, scalable, tractable systems biology framework to mechanistically link microbial strains and faecal met...

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Bibliographic Details
Main Authors: Almut Heinken, Johannes Hertel, Ines Thiele
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:npj Systems Biology and Applications
Online Access:https://doi.org/10.1038/s41540-021-00178-6