Nivolumab Reduces PD1 Expression and Alters Density and Proliferation of Tumor Infiltrating Immune Cells in a Tissue Slice Culture Model of Renal Cell Carcinoma

Nivolumab Reduces PD1 Expression and Alters Density and Proliferation of Tumor Infiltrating Immune Cells in a Tissue Slice Culture Model of Renal Cell Carcinoma

Background: In the treatment of clear cell renal cell carcinoma (ccRCC), nivolumab is an established component of the first-line therapy with a favorable impact on progression free survival and overall survival. However, treatment-related adverse effects occur and, to date, there is no approved pred...

Full description

Bibliographic Details
Main Authors: Philipp J. Stenzel, Nina Hörner, Sebastian Foersch, Daniel-Christoph Wagner, Igor Tsaur, Anita Thomas, Axel Haferkamp, Stephan Macher-Goeppinger, Wilfried Roth, Stefan Porubsky, Katrin E. Tagscherer
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Cancers
Subjects:
nivolumab
clear cell renal cell carcinoma
tissue slice culture
PD1
T-cells
Online Access:https://www.mdpi.com/2072-6694/13/18/4511

Internet

https://www.mdpi.com/2072-6694/13/18/4511

Similar Items