Human splice factors contribute to latent HIV infection in primary cell models and blood CD4+ T cells from ART-treated individuals.

Human splice factors contribute to latent HIV infection in primary cell models and blood CD4+ T cells from ART-treated individuals.

It is unclear what mechanisms govern latent HIV infection in vivo or in primary cell models. To investigate these questions, we compared the HIV and cellular transcription profile in three primary cell models and peripheral CD4+ T cells from HIV-infected ART-suppressed individuals using RT-ddPCR and...

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Bibliographic Details
Main Authors: Sara Moron-Lopez, Sushama Telwatte, Indra Sarabia, Emilie Battivelli, Mauricio Montano, Amanda B Macedo, Dvir Aran, Atul J Butte, R Brad Jones, Alberto Bosque, Eric Verdin, Warner C Greene, Joseph K Wong, Steven A Yukl
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-11-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1009060

Internet

https://doi.org/10.1371/journal.ppat.1009060

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