Synthesis, Tyrosinase Inhibiting Activity and Molecular Docking of Fluorinated Pyrazole Aldehydes as Phosphodiesterase Inhibitors

Synthesis, Tyrosinase Inhibiting Activity and Molecular Docking of Fluorinated Pyrazole Aldehydes as Phosphodiesterase Inhibitors

A series of fluorinated 4,5-dihydro-1<i>H</i>-pyrazole derivatives were synthesized in the reaction of corresponding acetophenone and different aldehydes followed by the second step synthesis of desired compounds from synthesized chalcone, hydrazine hydrate, and formic acid. Structures o...

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Bibliographic Details
Main Authors: Vesna Rastija, Harshad Brahmbhatt, Maja Molnar, Melita Lončarić, Ivica Strelec, Mario Komar, Valentina Pavić
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Applied Sciences
Subjects:
fluorinated pyrazole aldehydes
tyrosinase inhibition
phosphodiesterase inhibition
antibacterial activity
molecular docking
Online Access:https://www.mdpi.com/2076-3417/9/8/1704

Internet

https://www.mdpi.com/2076-3417/9/8/1704

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