Obstacles to detecting isoforms using full-length scRNA-seq data

Obstacles to detecting isoforms using full-length scRNA-seq data

Abstract Background Early single-cell RNA-seq (scRNA-seq) studies suggested that it was unusual to see more than one isoform being produced from a gene in a single cell, even when multiple isoforms were detected in matched bulk RNA-seq samples. However, these studies generally did not consider the i...

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Bibliographic Details
Main Authors: Jennifer Westoby, Pavel Artemov, Martin Hemberg, Anne Ferguson-Smith
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Genome Biology
Subjects:
scRNA-seq
Single cell
Alternative splicing
Isoform
Gene
Isoform choice
Online Access:http://link.springer.com/article/10.1186/s13059-020-01981-w

Internet

http://link.springer.com/article/10.1186/s13059-020-01981-w

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