Murine Endogenous Retroviruses Are Detectable in Patient-Derived Xenografts but Not in Patient-Individual Cell Lines of Human Colorectal Cancer

Murine Endogenous Retroviruses Are Detectable in Patient-Derived Xenografts but Not in Patient-Individual Cell Lines of Human Colorectal Cancer

Endogenous retroviruses are remnants of retroviral infections. In contrast to their human counterparts, murine endogenous retroviruses (mERV) still can synthesize infectious particles and retrotranspose. Xenotransplanted human cells have occasionally been described to be mERV infected. With genetic...

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Bibliographic Details
Main Authors: Stephanie Bock, Christina S. Mullins, Ernst Klar, Philippe Pérot, Claudia Maletzki, Michael Linnebacher
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Microbiology
Subjects:
mERV
expression
PDX
PDX-derived cell lines
CDX
colorectal cancer
Online Access:http://journal.frontiersin.org/article/10.3389/fmicb.2018.00789/full

Internet

http://journal.frontiersin.org/article/10.3389/fmicb.2018.00789/full

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