From heterogeneous healthcare data to disease-specific biomarker networks: A hierarchical Bayesian network approach.

In this work, we introduce an entirely data-driven and automated approach to reveal disease-associated biomarker and risk factor networks from heterogeneous and high-dimensional healthcare data. Our workflow is based on Bayesian networks, which are a popular tool for analyzing the interplay of bioma...

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Bibliographic Details
Main Authors: Ann-Kristin Becker, Marcus Dörr, Stephan B Felix, Fabian Frost, Hans J Grabe, Markus M Lerch, Matthias Nauck, Uwe Völker, Henry Völzke, Lars Kaderali
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-02-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1008735