Glycine N-methyltransferase inhibits aristolochic acid nephropathy by increasing CYP3A44 and decreasing NQO1 expression in female mouse hepatocytes

Glycine N-methyltransferase inhibits aristolochic acid nephropathy by increasing CYP3A44 and decreasing NQO1 expression in female mouse hepatocytes

Abstract Plants containing aristolochic acids (AA) are nephrotoxins. Glycine N-methyltransferase (GNMT) acts to bind environmental toxins such as benzo(a)pyrene and aflatoxin B1, translocate into nucleus, and alter hepatic metabolism. This study aims to determine the role of GNMT in AA-induced nephr...

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Bibliographic Details
Main Authors: Ming-Min Chang, Chang-Ni Lin, Cheng-Chieh Fang, Marcelo Chen, Peir-In Liang, Wei-Ming Li, Bi-Wen Yeh, Hung-Chi Cheng, Bu-Miin Huang, Wen-Jeng Wu, Yi-Ming Arthur Chen
Format: Article
Language:English
Published: Nature Publishing Group 2018-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-018-22298-6

Internet

https://doi.org/10.1038/s41598-018-22298-6

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