Characterization of astrocytes throughout life in wildtype and APP/PS1 mice after early-life stress exposure

Characterization of astrocytes throughout life in wildtype and APP/PS1 mice after early-life stress exposure

Abstract Background Early-life stress (ES) is an emerging risk factor for later life development of Alzheimer’s disease (AD). We have previously shown that ES modulates amyloid-beta pathology and the microglial response to it in the APPswe/PS1dE9 mouse model. Because astrocytes are key players in th...

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Bibliographic Details
Main Authors: Maralinde R. Abbink, Janssen M. Kotah, Lianne Hoeijmakers, Aline Mak, Genevieve Yvon-Durocher, Bram van der Gaag, Paul J. Lucassen, Aniko Korosi
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Journal of Neuroinflammation
Subjects:
GFAP
Early stress
Aβ pathology
APP/PS1
Astrocytes
Glia
Online Access:http://link.springer.com/article/10.1186/s12974-020-01762-z

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http://link.springer.com/article/10.1186/s12974-020-01762-z

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