Epigenetic regulation of cancer progression by EZH2: from biological insights to therapeutic potential

Epigenetic regulation of cancer progression by EZH2: from biological insights to therapeutic potential

Abstract Enhancer of zeste homolog 2 (EZH2), a histone methyltransferase and a catalytic component of PRC2, catalyzes tri-methylation of histone H3 at Lys 27 (H3K27me3) to regulate gene expression through epigenetic machinery. EZH2 also functions both as a transcriptional suppressor and a transcript...

Full description

Bibliographic Details
Main Authors: Lu Gan, Yanan Yang, Qian Li, Yi Feng, Tianshu Liu, Weijian Guo
Format: Article
Language:English
Published: BMC 2018-03-01
Series:Biomarker Research
Subjects:
EZH2
Epigenetic
Histone H3 Lys27 trimethylation
Cancer
Polycomb repressive complex
Online Access:http://link.springer.com/article/10.1186/s40364-018-0122-2

Internet

http://link.springer.com/article/10.1186/s40364-018-0122-2

Similar Items