S100A4+ macrophages facilitate zika virus invasion and persistence in the seminiferous tubules via interferon-gamma mediation.

S100A4+ macrophages facilitate zika virus invasion and persistence in the seminiferous tubules via interferon-gamma mediation.

Testicular invasion and persistence are features of Zika virus (ZIKV), but their mechanisms are still unknown. Here, we showed that S100A4+ macrophages, a myeloid macrophage subpopulation with susceptibility to ZIKV infection, facilitated ZIKV invasion and persistence in the seminiferous tubules. In...

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Bibliographic Details
Main Authors: Wei Yang, Yan-Hua Wu, Shuang-Qing Liu, Zi-Yang Sheng, Zi-Da Zhen, Rui-Qi Gao, Xiao-Yun Cui, Dong-Ying Fan, Zhi-Hai Qin, Ai-Hua Zheng, Pei-Gang Wang, Jing An
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-12-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1009019

Internet

https://doi.org/10.1371/journal.ppat.1009019

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