Huanglongmycin A-C, Cytotoxic Polyketides Biosynthesized by a Putative Type II Polyketide Synthase From Streptomyces sp. CB09001

Huanglongmycin A-C, Cytotoxic Polyketides Biosynthesized by a Putative Type II Polyketide Synthase From Streptomyces sp. CB09001

Three natural products of nonaketide biosynthetic origin, probably biosynthesized from nine molecules of malonyl-CoA, have been isolated. Herein we described the isolation and structure elucidation of huanglongmycin (HLM) A-C and identification of the putative hlm biosynthetic gene cluster from Stre...

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Bibliographic Details
Main Authors: Lin Jiang, Hong Pu, Jingxi Xiang, Meng Su, Xiaohui Yan, Dong Yang, Xiangcheng Zhu, Ben Shen, Yanwen Duan, Yong Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Chemistry
Subjects:
nonaketide
type II polyketide synthase
karstic cave
huanglongmycin
cytotoxicity
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2018.00254/full

Internet

https://www.frontiersin.org/article/10.3389/fchem.2018.00254/full

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