Brief Local Application of Progesterone via a Wearable Bioreactor Induces Long-Term Regenerative Response in Adult Xenopus Hindlimb

Brief Local Application of Progesterone via a Wearable Bioreactor Induces Long-Term Regenerative Response in Adult Xenopus Hindlimb

Summary: The induction of limb repair in adult vertebrates is a pressing, unsolved problem. Here, we characterize the effects of an integrated device that delivers drugs to severed hindlimbs of adult Xenopus laevis, which normally regenerate cartilaginous spikes after amputation. A wearable bioreact...

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Bibliographic Details
Main Authors: Celia Herrera-Rincon, Annie S. Golding, Kristine M. Moran, Christina Harrison, Christopher J. Martyniuk, Justin A. Guay, Julia Zaltsman, Hayley Carabello, David L. Kaplan, Michael Levin
Format: Article
Language:English
Published: Elsevier 2018-11-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718315730

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http://www.sciencedirect.com/science/article/pii/S2211124718315730

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