Parallel PI3K, AKT and mTOR inhibition is required to control feedback loops that limit tumor therapy.

Parallel PI3K, AKT and mTOR inhibition is required to control feedback loops that limit tumor therapy.

Targeting the PI3K pathway has achieved limited success in cancer therapy. One reason for the disappointing activity of drugs that interfere with molecules that are important player in this pathway is the induction of multiple feedback loops that have been only partially understood. To understand th...

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Bibliographic Details
Main Authors: Anuja Sathe, Géraldine Chalaud, Immanuel Oppolzer, Kit Yeng Wong, Margarita von Busch, Sebastian C Schmid, Zhichao Tong, Margitta Retz, Juergen E Gschwend, Wolfgang A Schulz, Roman Nawroth
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5777650?pdf=render

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http://europepmc.org/articles/PMC5777650?pdf=render

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