Diverse immune response of DNA damage repair-deficient tumors

Diverse immune response of DNA damage repair-deficient tumors

Summary: Tumors with DNA damage repair (DDR) deficiency accumulate genomic alterations that may serve as neoantigens and increase sensitivity to immune checkpoint inhibitor. However, over half of DDR-deficient tumors are refractory to immunotherapy, and it remains unclear which mutations may promote...

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Bibliographic Details
Main Authors: Tao Qing, Tomi Jun, Katherine E. Lindblad, Amaia Lujambio, Michal Marczyk, Lajos Pusztai, Kuan-lin Huang
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:Cell Reports Medicine
Subjects:
DNA damage repair deficiency
germline variant
somatic mutations
mismatch repair
methylation
tumor mutation burden
Online Access:http://www.sciencedirect.com/science/article/pii/S266637912100104X

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http://www.sciencedirect.com/science/article/pii/S266637912100104X

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