Pretreatment of Huoxue Jiedu Formula Ameliorates Myocardial Ischaemia/Reperfusion Injury by Decreasing Autophagy via Activation of the PI3K/AKT/mTOR Pathway

Pretreatment of Huoxue Jiedu Formula Ameliorates Myocardial Ischaemia/Reperfusion Injury by Decreasing Autophagy via Activation of the PI3K/AKT/mTOR Pathway

Background: Myocardial ischaemia/reperfusion (I/R) results in myocardial injury via excessive autophagy. Huoxue Jiedu Formula (HJF) has been widely applied in China for the treatment of ischaemic heart disease. However, the mechanisms of HJF are still poorly understood. Thus, the present experiment...

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Bibliographic Details
Main Authors: Linzi Long, Zikai Yu, ShengJun Chen, Jiarui Wu, Yingying Liu, Jun Peng, Hua Qu, Changgeng Fu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Pharmacology
Subjects:
ischaemia/reperfusion
network pharmacology
Chinese herb
PI3K-AKT pathway
autophagy
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.608790/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.608790/full

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