Different CFTR modulator combinations downregulate inflammation differently in cystic fibrosis

Different CFTR modulator combinations downregulate inflammation differently in cystic fibrosis

Previously, we showed that serum and monocytes from patients with CF exhibit an enhanced NLRP3-inflammasome signature with increased IL-18, IL-1β, caspase-1 activity and ASC speck release (Scambler et al. eLife 2019). Here we show that CFTR modulators down regulate this exaggerated proinflammatory r...

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Bibliographic Details
Main Authors: Heledd H Jarosz-Griffiths, Thomas Scambler, Chi H Wong, Samuel Lara-Reyna, Jonathan Holbrook, Fabio Martinon, Sinisa Savic, Paul Whitaker, Christine Etherington, Giulia Spoletini, Ian Clifton, Anil Mehta, Michael F McDermott, Daniel Peckham
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-03-01
Series:eLife
Subjects:
ivacaftor
lumacaftor
tezacaftor
cystic fibrosis
inflammation
nlrp3 inflammasome
Online Access:https://elifesciences.org/articles/54556

Internet

https://elifesciences.org/articles/54556

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