Structural and mechanistic basis of capsule O-acetylation in Neisseria meningitidis serogroup A

Structural and mechanistic basis of capsule O-acetylation in Neisseria meningitidis serogroup A

Neisseria meningitidis capsular polysaccharide (CPS) is a major virulence factor and vaccine formulations against Neisseria meningitidis serogroup A (NmA) contain O-acetylated CPS. Here, the authors provide mechanistic insights into CPS O-acetylation in NmA by determining the crystal structure of th...

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Bibliographic Details
Main Authors: Timm Fiebig, Johannes T. Cramer, Andrea Bethe, Petra Baruch, Ute Curth, Jana I. Führing, Falk F. R. Buettner, Ulrich Vogel, Mario Schubert, Roman Fedorov, Martina Mühlenhoff
Format: Article
Language:English
Published: Nature Publishing Group 2020-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-18464-y

Internet

https://doi.org/10.1038/s41467-020-18464-y

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