Dissemination of Orientia tsutsugamushi, a Causative Agent of Scrub Typhus, and Immunological Responses in the Humanized DRAGA Mouse

Dissemination of Orientia tsutsugamushi, a Causative Agent of Scrub Typhus, and Immunological Responses in the Humanized DRAGA Mouse

Scrub typhus is caused by Orientia tsutsugamushi, an obligated intracellular bacterium that affects over one million people per year. Several mouse models have been used to study its pathogenesis, disease immunology, and for testing vaccine candidates. However, due to the intrinsic differences betwe...

Full description

Bibliographic Details
Main Authors: Le Jiang, Erin K. Morris, Rodrigo Aguilera-Olvera, Zhiwen Zhang, Teik-Chye Chan, Soumya Shashikumar, Chien-Chung Chao, Sofia A. Casares, Wei-Mei Ching
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Immunology
Subjects:
scrub typhus
Orientia
mouse model
humanized mice
footpad inoculation
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00816/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00816/full

Similar Items