A general approach for detecting expressed mutations in AML cells using single cell RNA-sequencing

A general approach for detecting expressed mutations in AML cells using single cell RNA-sequencing

The advent of single-cell RNA sequencing has revealed significant transcriptional heterogeneity in cancer, but its relationship to genomic heterogeneity remains unclear. Focusing on acute myeloid leukemia samples, the authors describe a general approach for linking mutation-containing cells to their...

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Bibliographic Details
Main Authors: Allegra A. Petti, Stephen R. Williams, Christopher A. Miller, Ian T. Fiddes, Sridhar N. Srivatsan, David Y. Chen, Catrina C. Fronick, Robert S. Fulton, Deanna M. Church, Timothy J. Ley
Format: Article
Language:English
Published: Nature Publishing Group 2019-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-11591-1

Internet

https://doi.org/10.1038/s41467-019-11591-1

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