Flow cytometry and targeted immune transcriptomics identify distinct profiles in patients with chronic myeloid leukemia receiving tyrosine kinase inhibitors with or without interferon-α

Flow cytometry and targeted immune transcriptomics identify distinct profiles in patients with chronic myeloid leukemia receiving tyrosine kinase inhibitors with or without interferon-α

Abstract Background Tumor cells have evolved complex strategies to escape immune surveillance, a process which involves NK cells and T lymphocytes, and various immunological factors. Indeed, tumor cells recruit immunosuppressive cells [including regulatory T-cells (Treg), myeloid-derived suppressor...

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Bibliographic Details
Main Authors: Raquel Alves, Stephanie E. B. McArdle, Jayakumar Vadakekolathu, Ana Cristina Gonçalves, Paulo Freitas-Tavares, Amélia Pereira, Antonio M. Almeida, Ana Bela Sarmento-Ribeiro, Sergio Rutella
Format: Article
Language:English
Published: BMC 2020-01-01
Series:Journal of Translational Medicine
Subjects:
Chronic myeloid leukemia
Interferon
Immunotherapy
Gene expression profiling
Immune monitoring
Online Access:https://doi.org/10.1186/s12967-019-02194-x

Internet

https://doi.org/10.1186/s12967-019-02194-x

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