Modifying inter-cistronic sequence significantly enhances IRES dependent second gene expression in bicistronic vector: Construction of optimised cassette for gene therapy of familial hypercholesterolemia

Modifying inter-cistronic sequence significantly enhances IRES dependent second gene expression in bicistronic vector: Construction of optimised cassette for gene therapy of familial hypercholesterolemia

Internal ribosome entry site (IRES) sequences have become a valuable tool in the construction of gene transfer and therapeutic vectors for multi-cistronic gene expression from a single mRNA transcript. The optimal conditions for effective use of this sequence to construct a functional expression vec...

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Bibliographic Details
Main Authors: Faisal A. Al-Allaf, Zainularifeen Abduljaleel, Mohammad Athar, Mohiuddin M. Taher, Wajahatullah Khan, Huseyin Mehmet, Mukaddes Colakogullari, Sophia Apostolidou, Brian Bigger, Simon Waddington, Charles Coutelle, Michael Themis, Mohammed N. Al-Ahdal, Futwan A. Al-Mohanna, Zuhair N. Al-Hassnan, Abdellatif Bouazzaoui
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2019-03-01
Series:Non-coding RNA Research
Online Access:http://www.sciencedirect.com/science/article/pii/S246805401830088X

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http://www.sciencedirect.com/science/article/pii/S246805401830088X

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