Genetic Targeting of GRP78 in the VMH Improves Obesity Independently of Food Intake

Genetic Targeting of GRP78 in the VMH Improves Obesity Independently of Food Intake

Recent data have demonstrated that the hypothalamic GRP78/BiP (glucose regulated protein 78 kDa/binding immunoglobulin protein) modulates brown adipose tissue (BAT) thermogenesis by acting downstream on AMP-activated protein kinase (AMPK). Herein, we aimed to investigate whether genetic over-express...

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Bibliographic Details
Main Authors: Laura Liñares-Pose, Eva Rial-Pensado, Ánxela Estévez-Salguero, Edward Milbank, Ismael González-García, Claudia Rodríguez, Patricia Seoane-Collazo, Noelia Martinez-Sánchez, Rubén Nogueiras, Dolores Prieto, Carlos Diéguez, Cristina Contreras, Miguel López
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:Genes
Subjects:
brown adipose tissue
browning
ER stress
GRP78
hypothalamus
thermogenesis
white adipose tissue
Online Access:http://www.mdpi.com/2073-4425/9/7/357

Internet

http://www.mdpi.com/2073-4425/9/7/357

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