Zeb1 and SK3 Channel Are Up-Regulated in Castration-Resistant Prostate Cancer and Promote Neuroendocrine Differentiation

Zeb1 and SK3 Channel Are Up-Regulated in Castration-Resistant Prostate Cancer and Promote Neuroendocrine Differentiation

Therapeutic strategies for metastatic castration-resistant prostate cancer aim to target androgen receptor signaling. Despite initial survival benefits, treatment resistance invariably occurs, leading to lethal disease. Therapies targeting the androgen receptor can induce the emergence of a neuroend...

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Bibliographic Details
Main Authors: Fanny Bery, Mathilde Cancel, Maxime Guéguinou, Marie Potier-Cartereau, Christophe Vandier, Aurélie Chantôme, Roseline Guibon, Franck Bruyère, Gaëlle Fromont, Karine Mahéo
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Cancers
Subjects:
prostate cancer
neuroendocrine differenciation
epithelial to mesenchymal transition
calcium signaling
Online Access:https://www.mdpi.com/2072-6694/13/12/2947

Internet

https://www.mdpi.com/2072-6694/13/12/2947

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