Flagellin attenuates experimental sepsis in a macrophage-dependent manner
Abstract Background Sepsis is the leading cause of death among critically ill patients, and no specific therapeutic agent is currently approved for the treatment of sepsis. Methods We assessed the effects of flagellin administration on survival, bacterial burden, and tissue injury after sepsis. In a...
Main Authors: | Xiaoliang Yang, Yibing Yin, Xingxing Yan, Zebo Yu, Yi Liu, Ju Cao |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2019-04-01
|
Series: | Critical Care |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s13054-019-2408-7 |
Similar Items
-
Flagellin/TLR5 Stimulate Myeloid Progenitors to Enter Lung Tissue and to Locally Differentiate Into Macrophages
by: Xin Lei, et al.
Published: (2021-03-01) -
Rôle des récepteurs Toll-like et de CD14 dans la réponse à Listeria monocytogenes et à la flagelline extraite de Salmonella typhimurium
by: Janot, Laure
Published: (2009) -
TLR5-dependent immunogenicity of a recombinant fusion protein containing an immunodominant epitope of malarial circumsporozoite protein and the FliC flagellin of Salmonella Typhimurium
by: Ariane Guglielmi Ariza Camacho, et al.
Published: (2011-08-01) -
The Bacterial Component Flagellin Induces Anti-Sepsis Protection Through TLR-5, IL-1RN and VCAN During Polymicrobial Sepsis in Mice
by: Jiang Zhu, et al.
Published: (2015-05-01) -
The Remarkable Dual-Level Diversity of Prokaryotic Flagellins
by: Dalong Hu, et al.
Published: (2020-02-01)