CRISPR-Cas9 Ribonucleoprotein-Mediated Genomic Editing in Mature Primary Innate Immune Cells

CRISPR-Cas9 Ribonucleoprotein-Mediated Genomic Editing in Mature Primary Innate Immune Cells

Summary: CRISPR genome engineering has become a powerful tool to functionally investigate the complex mechanisms of immune system regulation. While decades of work have aimed to genetically reprogram innate immunity, the utility of current approaches is restricted by poor knockout efficiencies or li...

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Bibliographic Details
Main Authors: Luke Riggan, Andrew D. Hildreth, Marion Rolot, Yung-Yu Wong, William Satyadi, Ryan Sun, Christopher Huerta, Timothy E. O’Sullivan
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:Cell Reports
Subjects:
CRISPR
Cas9
cRNP
innate immunity
ILC
dendritic cell
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720306045

Internet

http://www.sciencedirect.com/science/article/pii/S2211124720306045

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