Age Induced Nitroso-Redox Imbalance Leads to Subclinical Hypogonadism in Male Mice

Age Induced Nitroso-Redox Imbalance Leads to Subclinical Hypogonadism in Male Mice

Objective: The cause of age-related changes in testosterone remains unclear. We hypothesized that increased nitroso-redox imbalance with aging could affect testosterone production.Materials and Methods: We measured several markers of nitroso-redox imbalance (4-HNE, 3-NT, and NT) in serum of S-nitros...

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Bibliographic Details
Main Authors: John Alden Lee, Manish Kuchakulla, Himanshu Arora, Shathiyah Kulandavelu, Evert Gonzalez, Thomas A. Masterson, Joshua M. Hare, Ursula B. Kaiser, Ranjith Ramasamy
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Endocrinology
Subjects:
subclinical hypogonadism
compensated hypogonadism
aging
nitroso-redox imbalance
nitrosative stress
4-hydroxynonenal
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2019.00190/full

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https://www.frontiersin.org/article/10.3389/fendo.2019.00190/full

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