Nuclear Factor I/B: A Master Regulator of Cell Differentiation with Paradoxical Roles in Cancer

Nuclear Factor I/B: A Master Regulator of Cell Differentiation with Paradoxical Roles in Cancer

Emerging evidence indicates that nuclear factor I/B (NFIB), a transcription factor required for proper development and regulation of cellular differentiation in several tissues, also plays critical roles in cancer. Despite being a metastatic driver in small cell lung cancer and melanoma, it has beco...

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Bibliographic Details
Main Authors: Daiana D. Becker-Santos, Kim M. Lonergan, Richard M. Gronostajski, Wan L. Lam
Format: Article
Language:English
Published: Elsevier 2017-08-01
Series:EBioMedicine
Subjects:
Cancer
Oncogene
Tumour suppressor
Cellular differentiation
NFIB
Developmental transcription factor
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396417302256

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http://www.sciencedirect.com/science/article/pii/S2352396417302256

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