MOMO - multi-objective metabolic mixed integer optimization: application to yeast strain engineering

Abstract Background In this paper, we explore the concept of multi-objective optimization in the field of metabolic engineering when both continuous and integer decision variables are involved in the model. In particular, we propose a multi-objective model that may be used to suggest reaction deleti...

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Bibliographic Details
Main Authors: Ricardo Andrade, Mahdi Doostmohammadi, João L. Santos, Marie-France Sagot, Nuno P. Mira, Susana Vinga
Format: Article
Language:English
Published: BMC 2020-02-01
Series:BMC Bioinformatics
Subjects:
Online Access:http://link.springer.com/article/10.1186/s12859-020-3377-1