A Qualitative Change in the Transcriptome Occurs after the First Cell Cycle and Coincides with Lumen Establishment during MDCKII Cystogenesis

A Qualitative Change in the Transcriptome Occurs after the First Cell Cycle and Coincides with Lumen Establishment during MDCKII Cystogenesis

Summary: Madin-Darby canine kidney II (MDCKII) cells are widely used to study epithelial morphogenesis. To better understand this process, we performed time course RNA-seq analysis of MDCKII 3D cystogenesis, along with polarized 2D cells for comparison. Our study reveals a biphasic change in the tra...

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Bibliographic Details
Main Authors: Tianfang Wang, Sang-Ho Kwon, Xiao Peng, Severine Urdy, Zefu Lu, Robert J. Schmitz, Stephen Dalton, Keith E. Mostov, Shaying Zhao
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:iScience
Subjects:
Developmental Biology
Embryology
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S258900422030821X

Internet

http://www.sciencedirect.com/science/article/pii/S258900422030821X

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