Metabolic Responses to Dietary Protein Restriction Require an Increase in FGF21 that Is Delayed by the Absence of GCN2

Metabolic Responses to Dietary Protein Restriction Require an Increase in FGF21 that Is Delayed by the Absence of GCN2

FGF21 contributes to the metabolic response to dietary protein restriction, and prior data implicate GCN2 as the amino acid sensor linking protein restriction to FGF21 induction. Here, we demonstrate the persistent and essential role of FGF21 in the metabolic response to protein restriction. We show...

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Bibliographic Details
Main Authors: Thomas Laeger, Diana C. Albarado, Susan J. Burke, Lexus Trosclair, John W. Hedgepeth, Hans-Rudolf Berthoud, Thomas W. Gettys, J. Jason Collier, Heike Münzberg, Christopher D. Morrison
Format: Article
Language:English
Published: Elsevier 2016-07-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716307987

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http://www.sciencedirect.com/science/article/pii/S2211124716307987

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