Use of Modified <em>Clostridium perfringens</em> Enterotoxin Fragments for Claudin Targeting in Liver and Skin Cells

Use of Modified <em>Clostridium perfringens</em> Enterotoxin Fragments for Claudin Targeting in Liver and Skin Cells

Claudins regulate paracellular permeability in different tissues. The claudin-binding domain of <i>Clostridium perfringens</i> enterotoxin (cCPE) is a known modulator of a claudin subset. However, it does not efficiently bind to claudin-1 (Cldn1). Cldn1 is a pharmacological target since...

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Bibliographic Details
Main Authors: Laura-Sophie Beier, Jan Rossa, Stephen Woodhouse, Sophia Bergmann, Holger B. Kramer, Jonas Protze, Miriam Eichner, Anna Piontek, Sabine Vidal-y-Sy, Johanna M. Brandner, Gerd Krause, Nicole Zitzmann, Jörg Piontek
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:International Journal of Molecular Sciences
Subjects:
<i>clostridium perfringens</i> enterotoxin
claudin-1
hepatitis c virus
viral entry
epidermal barrier
reconstructed human epidermis
claudin targeting
Online Access:https://www.mdpi.com/1422-0067/20/19/4774

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https://www.mdpi.com/1422-0067/20/19/4774

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