Stereoselective Chemoenzymatic Synthesis of Optically Active Aryl-Substituted Oxygen-Containing Heterocycles

Stereoselective Chemoenzymatic Synthesis of Optically Active Aryl-Substituted Oxygen-Containing Heterocycles

A two-step stereoselective chemoenzymatic synthesis of optically active α-aryl-substituted oxygen heterocycles was developed, exploiting a whole-cell mediated asymmetric reduction of α-, β-, and γ-chloroalkyl arylketones followed by a stereospecific cyclization of the corresponding chlorohydrins int...

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Bibliographic Details
Main Authors: Paola Vitale, Antonia Digeo, Filippo Maria Perna, Gennaro Agrimi, Antonio Salomone, Antonio Scilimati, Cosimo Cardellicchio, Vito Capriati
Format: Article
Language:English
Published: MDPI AG 2017-01-01
Series:Catalysts
Subjects:
whole cell biocatalyst
baker’s yeast
enantioselective bioreduction
oxiranes
oxetanes
tetrahydrofurans
halohydrins
chloroketones
oxygen-containing heterocycles
chemoenzymatic synthesis
Online Access:http://www.mdpi.com/2073-4344/7/2/37

Internet

http://www.mdpi.com/2073-4344/7/2/37

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