Design, synthesis and molecular modelling studies of some pyrazole derivatives as carbonic anhydrase inhibitors

Design, synthesis and molecular modelling studies of some pyrazole derivatives as carbonic anhydrase inhibitors

In this study, newly synthesised compounds 6, 8, 10 and other compounds (1–5, 7 and 9) and their inhibitory properties against the human isoforms hCA I and hCA II were reported for the first time. Compounds 1–10 showed effective inhibition profiles with KI values in the range of 5.13–16.9 nM for hCA...

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Bibliographic Details
Main Authors: Yazgı Dizdaroglu, Canan Albay, Tayfun Arslan, Abdulilah Ece, Emir A. Turkoglu, Asiye Efe, Murat Senturk, Claudiu T. Supuran, Deniz Ekinci
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
pyrazole
carbonic anhydrase
molecular docking
adme
Online Access:http://dx.doi.org/10.1080/14756366.2019.1695791

Internet

http://dx.doi.org/10.1080/14756366.2019.1695791

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