Wharton’s jelly mesenchymal stem cell-based or umbilical vein endothelial cell-based serum-free coculture with cytokines supports the ex vivo expansion/maintenance of cord blood hematopoietic stem/progenitor cells

Wharton’s jelly mesenchymal stem cell-based or umbilical vein endothelial cell-based serum-free coculture with cytokines supports the ex vivo expansion/maintenance of cord blood hematopoietic stem/progenitor cells

Abstract Background The umbilical cord blood (UCB) has been widely accepted as an alternative source of hematopoietic stem/progenitor cells (HSPCs) for transplantation, and its use in adults is still restricted because of low absolute numbers. To overcome this obstacle, expansion of UCB-HSPCs under...

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Bibliographic Details
Main Authors: Qiuyang Li, Dewan Zhao, Qiang Chen, Maowen Luo, Jingcao Huang, Cao Yang, Fangfang Wang, Wenxian Li, Ting Liu
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Stem Cell Research & Therapy
Subjects:
Hematopoietic stem/progenitor cells
Expansion in vitro
Serum-free culture
Cytokines
Wharton’s jelly mesenchymal stem cells
Umbilical vein endothelial cells
Online Access:https://doi.org/10.1186/s13287-019-1502-8

Internet

https://doi.org/10.1186/s13287-019-1502-8

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