Comparative transcriptomics of choroid plexus in Alzheimer’s disease, frontotemporal dementia and Huntington’s disease: implications for CSF homeostasis

Comparative transcriptomics of choroid plexus in Alzheimer’s disease, frontotemporal dementia and Huntington’s disease: implications for CSF homeostasis

Abstract Background In Alzheimer’s disease, there are striking changes in CSF composition that relate to altered choroid plexus (CP) function. Studying CP tissue gene expression at the blood–cerebrospinal fluid barrier could provide further insight into the epithelial and stromal responses to neurod...

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Bibliographic Details
Main Authors: Edward G. Stopa, Keith Q. Tanis, Miles C. Miller, Elena V. Nikonova, Alexei A. Podtelezhnikov, Eva M. Finney, David J. Stone, Luiz M. Camargo, Lisan Parker, Ajay Verma, Andrew Baird, John E. Donahue, Tara Torabi, Brian P. Eliceiri, Gerald D. Silverberg, Conrad E. Johanson
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Fluids and Barriers of the CNS
Subjects:
Choroid plexus transcriptome
Neuroimmune CSF regulation
Blood–CSF barrier inflammatome
Janus kinase/signal transducers and activators of transcription (JAK-STAT)
Peroxisome-proliferator-activated receptor (PPAR)
Cadherin-mediated adhesion
Online Access:http://link.springer.com/article/10.1186/s12987-018-0102-9

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http://link.springer.com/article/10.1186/s12987-018-0102-9

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