Endochin-Like Quinolones Exhibit Promising Efficacy Against Neospora Caninum in vitro and in Experimentally Infected Pregnant Mice

Endochin-Like Quinolones Exhibit Promising Efficacy Against Neospora Caninum in vitro and in Experimentally Infected Pregnant Mice

We report on the efficacy of selected endochin-like quinolones (ELQs) against N. caninum tachyzoites grown in human foreskin fibroblasts (HFF), and in a pregnant BALB/c mouse model. Fourteen ELQs were screened against transgenic N. caninum tachyzoites expressing β-galactosidase (Nc-βgal). Drugs were...

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Bibliographic Details
Main Authors: Nicoleta Anghel, Vreni Balmer, Joachim Müller, Pablo Winzer, Adriana Aguado-Martinez, Mona Roozbehani, Sovitj Pou, Aaron Nilsen, Michael Riscoe, J. Stone Doggett, Andrew Hemphill
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Veterinary Science
Subjects:
Neospora
Toxoplasma
endochin-like quinolones
mitochondrion
cytochromeb
electron microscopy
Online Access:https://www.frontiersin.org/article/10.3389/fvets.2018.00285/full

Internet

https://www.frontiersin.org/article/10.3389/fvets.2018.00285/full

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