CD1b Tetramers Broadly Detect T Cells That Correlate With Mycobacterial Exposure but Not Tuberculosis Disease State

CD1b Tetramers Broadly Detect T Cells That Correlate With Mycobacterial Exposure but Not Tuberculosis Disease State

The non-polymorphic nature of CD1 proteins creates a situation in which T cells with invariant T cell receptors (TCRs), like CD1d-specific NKT cells, are present in all humans. CD1b is an abundant protein on human dendritic cells that presents M. tuberculosis (Mtb) lipid antigens to T cells. Analysi...

Full description

Bibliographic Details
Main Authors: Kattya Lopez, Sarah K. Iwany, Sara Suliman, Josephine F. Reijneveld, Tonatiuh A. Ocampo, Judith Jimenez, Roger Calderon, Leonid Lecca, Megan B. Murray, D. Branch Moody, Ildiko Van Rhijn
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Immunology
Subjects:
tuberculosis
T cell receptor
CD1b
tetramer
glycolipids
mycobacteria
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00199/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00199/full

Similar Items