Ethylenation of aldehydes to 3-propanal, propanol and propanoic acid derivatives

Abstract Methodology has been developed for the synthesis of 3-propanaldehydes through a five-step process in 11–67% yield from aldehydes. Aldehydes were reacted with Meldrum’s acid through a Knoevenagel condensation to give materials that upon reduction with sodium borohydride and subsequent hydrol...

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Bibliographic Details
Main Authors: Daniel T. Payne, Yiming Zhao, John S. Fossey
Format: Article
Language:English
Published: Nature Publishing Group 2017-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-01950-7