Type I Interferons Suppress Anti-parasitic Immunity and Can Be Targeted to Improve Treatment of Visceral Leishmaniasis

Type I Interferons Suppress Anti-parasitic Immunity and Can Be Targeted to Improve Treatment of Visceral Leishmaniasis

Summary: Type I interferons (IFNs) play critical roles in anti-viral and anti-tumor immunity. However, they also suppress protective immune responses in some infectious diseases. Here, we identify type I IFNs as major upstream regulators of CD4+ T cells from visceral leishmaniasis (VL) patients. Fur...

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Bibliographic Details
Main Authors: Rajiv Kumar, Patrick T. Bunn, Siddharth Sankar Singh, Susanna S. Ng, Marcela Montes de Oca, Fabian De Labastida Rivera, Shashi Bhushan Chauhan, Neetu Singh, Rebecca J. Faleiro, Chelsea L. Edwards, Teija C.M. Frame, Meru Sheel, Rebecca J. Austin, Steven W. Lane, Tobias Bald, Mark J. Smyth, Geoffrey.R. Hill, Shannon E. Best, Ashraful Haque, Dillon Corvino, Nic Waddell, Lambross Koufariotis, Pamela Mukhopadhay, Madhukar Rai, Jaya Chakravarty, Om Prakash Singh, David Sacks, Susanne Nylen, Jude Uzonna, Shyam Sundar, Christian R. Engwerda
Format: Article
Language:English
Published: Elsevier 2020-02-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720301339

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http://www.sciencedirect.com/science/article/pii/S2211124720301339

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