Rational polytherapy in the treatment of cholinergic seizures

Rational polytherapy in the treatment of cholinergic seizures

The initiation and maintenance phases of cholinergic status epilepticus (SE) are associated with maladaptive trafficking of synaptic GABAA and glutamate receptors. The resulting pharmacoresistance reflects a decrease in synaptic GABAA receptors and increase in NMDA and AMPA receptors, which tilt the...

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Bibliographic Details
Main Authors: Jerome Niquet, Lucille Lumley, Roger Baldwin, Franco Rossetti, Lucie Suchomelova, David Naylor, Ireri Betsabe Franco Estrada, Mark Schultz, Marcio de Araujo Furtado, Claude G. Wasterlain
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Neurobiology of Disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996119302050

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http://www.sciencedirect.com/science/article/pii/S0969996119302050

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