The major secreted protein of the whipworm parasite tethers to matrix and inhibits interleukin-13 function
In the study, the authors identify a protein excreted by the parasite Trichuris muris, p43, which can modulate IL-13 function, a key cytokine involved in host protection. These data suggest that p43 may be a novel therapeutic target for both whipworm infections and IL13 mediated pathologies.
| Main Authors: | , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2019-05-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-09996-z |
| id |
doaj-e790a9921fd644c2949b6cd1e5687605 |
|---|---|
| record_format |
Article |
| spelling |
doaj-e790a9921fd644c2949b6cd1e56876052021-05-11T11:27:54ZengNature Publishing GroupNature Communications2041-17232019-05-0110111110.1038/s41467-019-09996-zThe major secreted protein of the whipworm parasite tethers to matrix and inhibits interleukin-13 functionAllison J. Bancroft0Colin W. Levy1Thomas A. Jowitt2Kelly S. Hayes3Seona Thompson4Edward A. Mckenzie5Matthew D. Ball6Eamon Dubaissi7Aidan P. France8Bruno Bellina9Catherine Sharpe10Aleksandr Mironov11Sheila L. Brown12Peter C. Cook13Andrew S. MacDonald14David J. Thornton15Richard K. Grencis16Lydia Becker Institute for Immunology and InflammationManchester Institute of Biotechnology, University of ManchesterWellcome Trust Centre for Cell Matrix ResearchLydia Becker Institute for Immunology and InflammationLydia Becker Institute for Immunology and InflammationManchester Institute of Biotechnology, University of ManchesterManchester Institute of Biotechnology, University of ManchesterLydia Becker Institute for Immunology and InflammationManchester Institute of Biotechnology, University of ManchesterManchester Institute of Biotechnology, University of ManchesterLydia Becker Institute for Immunology and InflammationSchool of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of ManchesterLydia Becker Institute for Immunology and InflammationLydia Becker Institute for Immunology and InflammationLydia Becker Institute for Immunology and InflammationLydia Becker Institute for Immunology and InflammationLydia Becker Institute for Immunology and InflammationIn the study, the authors identify a protein excreted by the parasite Trichuris muris, p43, which can modulate IL-13 function, a key cytokine involved in host protection. These data suggest that p43 may be a novel therapeutic target for both whipworm infections and IL13 mediated pathologies.https://doi.org/10.1038/s41467-019-09996-z |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Allison J. Bancroft Colin W. Levy Thomas A. Jowitt Kelly S. Hayes Seona Thompson Edward A. Mckenzie Matthew D. Ball Eamon Dubaissi Aidan P. France Bruno Bellina Catherine Sharpe Aleksandr Mironov Sheila L. Brown Peter C. Cook Andrew S. MacDonald David J. Thornton Richard K. Grencis |
| spellingShingle |
Allison J. Bancroft Colin W. Levy Thomas A. Jowitt Kelly S. Hayes Seona Thompson Edward A. Mckenzie Matthew D. Ball Eamon Dubaissi Aidan P. France Bruno Bellina Catherine Sharpe Aleksandr Mironov Sheila L. Brown Peter C. Cook Andrew S. MacDonald David J. Thornton Richard K. Grencis The major secreted protein of the whipworm parasite tethers to matrix and inhibits interleukin-13 function Nature Communications |
| author_facet |
Allison J. Bancroft Colin W. Levy Thomas A. Jowitt Kelly S. Hayes Seona Thompson Edward A. Mckenzie Matthew D. Ball Eamon Dubaissi Aidan P. France Bruno Bellina Catherine Sharpe Aleksandr Mironov Sheila L. Brown Peter C. Cook Andrew S. MacDonald David J. Thornton Richard K. Grencis |
| author_sort |
Allison J. Bancroft |
| title |
The major secreted protein of the whipworm parasite tethers to matrix and inhibits interleukin-13 function |
| title_short |
The major secreted protein of the whipworm parasite tethers to matrix and inhibits interleukin-13 function |
| title_full |
The major secreted protein of the whipworm parasite tethers to matrix and inhibits interleukin-13 function |
| title_fullStr |
The major secreted protein of the whipworm parasite tethers to matrix and inhibits interleukin-13 function |
| title_full_unstemmed |
The major secreted protein of the whipworm parasite tethers to matrix and inhibits interleukin-13 function |
| title_sort |
major secreted protein of the whipworm parasite tethers to matrix and inhibits interleukin-13 function |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2019-05-01 |
| description |
In the study, the authors identify a protein excreted by the parasite Trichuris muris, p43, which can modulate IL-13 function, a key cytokine involved in host protection. These data suggest that p43 may be a novel therapeutic target for both whipworm infections and IL13 mediated pathologies. |
| url |
https://doi.org/10.1038/s41467-019-09996-z |
| work_keys_str_mv |
AT allisonjbancroft themajorsecretedproteinofthewhipwormparasitetetherstomatrixandinhibitsinterleukin13function AT colinwlevy themajorsecretedproteinofthewhipwormparasitetetherstomatrixandinhibitsinterleukin13function AT thomasajowitt themajorsecretedproteinofthewhipwormparasitetetherstomatrixandinhibitsinterleukin13function AT kellyshayes themajorsecretedproteinofthewhipwormparasitetetherstomatrixandinhibitsinterleukin13function AT seonathompson themajorsecretedproteinofthewhipwormparasitetetherstomatrixandinhibitsinterleukin13function AT edwardamckenzie themajorsecretedproteinofthewhipwormparasitetetherstomatrixandinhibitsinterleukin13function AT matthewdball themajorsecretedproteinofthewhipwormparasitetetherstomatrixandinhibitsinterleukin13function AT eamondubaissi themajorsecretedproteinofthewhipwormparasitetetherstomatrixandinhibitsinterleukin13function AT aidanpfrance themajorsecretedproteinofthewhipwormparasitetetherstomatrixandinhibitsinterleukin13function AT brunobellina themajorsecretedproteinofthewhipwormparasitetetherstomatrixandinhibitsinterleukin13function AT catherinesharpe themajorsecretedproteinofthewhipwormparasitetetherstomatrixandinhibitsinterleukin13function AT aleksandrmironov themajorsecretedproteinofthewhipwormparasitetetherstomatrixandinhibitsinterleukin13function AT sheilalbrown themajorsecretedproteinofthewhipwormparasitetetherstomatrixandinhibitsinterleukin13function AT peterccook themajorsecretedproteinofthewhipwormparasitetetherstomatrixandinhibitsinterleukin13function AT andrewsmacdonald themajorsecretedproteinofthewhipwormparasitetetherstomatrixandinhibitsinterleukin13function AT davidjthornton themajorsecretedproteinofthewhipwormparasitetetherstomatrixandinhibitsinterleukin13function AT richardkgrencis themajorsecretedproteinofthewhipwormparasitetetherstomatrixandinhibitsinterleukin13function AT allisonjbancroft majorsecretedproteinofthewhipwormparasitetetherstomatrixandinhibitsinterleukin13function AT colinwlevy majorsecretedproteinofthewhipwormparasitetetherstomatrixandinhibitsinterleukin13function AT thomasajowitt majorsecretedproteinofthewhipwormparasitetetherstomatrixandinhibitsinterleukin13function AT kellyshayes majorsecretedproteinofthewhipwormparasitetetherstomatrixandinhibitsinterleukin13function AT seonathompson majorsecretedproteinofthewhipwormparasitetetherstomatrixandinhibitsinterleukin13function AT edwardamckenzie majorsecretedproteinofthewhipwormparasitetetherstomatrixandinhibitsinterleukin13function AT matthewdball majorsecretedproteinofthewhipwormparasitetetherstomatrixandinhibitsinterleukin13function AT eamondubaissi majorsecretedproteinofthewhipwormparasitetetherstomatrixandinhibitsinterleukin13function AT aidanpfrance majorsecretedproteinofthewhipwormparasitetetherstomatrixandinhibitsinterleukin13function AT brunobellina majorsecretedproteinofthewhipwormparasitetetherstomatrixandinhibitsinterleukin13function AT catherinesharpe majorsecretedproteinofthewhipwormparasitetetherstomatrixandinhibitsinterleukin13function AT aleksandrmironov majorsecretedproteinofthewhipwormparasitetetherstomatrixandinhibitsinterleukin13function AT sheilalbrown majorsecretedproteinofthewhipwormparasitetetherstomatrixandinhibitsinterleukin13function AT peterccook majorsecretedproteinofthewhipwormparasitetetherstomatrixandinhibitsinterleukin13function AT andrewsmacdonald majorsecretedproteinofthewhipwormparasitetetherstomatrixandinhibitsinterleukin13function AT davidjthornton majorsecretedproteinofthewhipwormparasitetetherstomatrixandinhibitsinterleukin13function AT richardkgrencis majorsecretedproteinofthewhipwormparasitetetherstomatrixandinhibitsinterleukin13function |
| _version_ |
1721446586661208064 |