Immunity to Soil-Transmitted Helminths: Evidence From the Field and Laboratory Models

by Stefano A. P. Colombo, Richard K. Grencis
Published 2020-06-01

Trickle infection and immunity to Trichuris muris.

by Maya Glover, Stefano A P Colombo, David J Thornton, Richard K Grencis
Published 2019-11-01

Adaptive immunity alters distinct host feeding pathways during nematode induced inflammation, a novel mechanism in parasite expulsion.

by John J Worthington, Linda C Samuelson, Richard K Grencis, John T McLaughlin
Published 2013-01-01

Regulatory RNAs: A Universal Language for Inter-Domain Communication

by Emma Layton, Anna-Marie Fairhurst, Sam Griffiths-Jones, Richard K. Grencis, Ian S. Roberts
Published 2020-11-01

Serine protease(s) secreted by the nematode Trichuris muris degrade the mucus barrier.

by Sumaira Z Hasnain, Michael A McGuckin, Richard K Grencis, David J Thornton
Published 2012-01-01

Functional Characterization of the Oxantel-Sensitive Acetylcholine Receptor from <i>Trichuris muris</i>

by Tina V. A. Hansen, Richard K. Grencis, Mohamed Issouf, Cédric Neveu, Claude L. Charvet
Published 2021-07-01

Chronic Trichuris muris Infection in C57BL/6 Mice Causes Significant Changes in Host Microbiota and Metabolome: Effects Reversed by Pathogen Clearance.

by Ashley Houlden, Kelly S Hayes, Allison J Bancroft, John J Worthington, Ping Wang, Richard K Grencis, Ian S Roberts
Published 2015-01-01

Chronic Trichuris muris infection causes neoplastic change in the intestine and exacerbates tumour formation in APC min/+ mice.

by Kelly S Hayes, Laura J Cliffe, Alison J Bancroft, Simon P Forman, Seona Thompson, Cath Booth, Richard K Grencis
Published 2017-06-01

Intestinal helminth co-infection is an unrecognised risk factor for increased pneumococcal carriage density and invasive disease

by Alice E. Law, Rebecca K. Shears, Andrea A. Lopez Rodas, Richard K. Grencis, Philip J. Cooper, Daniel R. Neill, Aras Kadioglu
Published 2021-03-01

Immune-driven alterations in mucin sulphation is an important mediator of Trichuris muris helminth expulsion.

by Sumaira Z Hasnain, Paul A Dawson, Rohan Lourie, Peter Hutson, Hui Tong, Richard K Grencis, Michael A McGuckin, David J Thornton
Published 2017-02-01

Loss of the TGFβ-activating integrin αvβ8 on dendritic cells protects mice from chronic intestinal parasitic infection via control of type 2 immunity.

by John J Worthington, Joanna E Klementowicz, Sayema Rahman, Beata I Czajkowska, Catherine Smedley, Herman Waldmann, Tim Sparwasser, Richard K Grencis, Mark A Travis
Published 2013-01-01

TGFβ-activation by dendritic cells drives Th17 induction and intestinal contractility and augments the expulsion of the parasite Trichinella spiralis in mice.

by Nicola Steel, Aduragbemi A Faniyi, Sayema Rahman, Stefanie Swietlik, Beata I Czajkowska, Bethany T Chan, Alexander Hardgrave, Anthony Steel, Tim D Sparwasser, Mushref B Assas, Richard K Grencis, Mark A Travis, John J Worthington
Published 2019-04-01

The autophagy gene Atg16l1 differentially regulates Treg and TH2 cells to control intestinal inflammation

by Agnieszka M Kabat, Oliver J Harrison, Thomas Riffelmacher, Amin E Moghaddam, Claire F Pearson, Adam Laing, Lucie Abeler-Dörner, Simon P Forman, Richard K Grencis, Quentin Sattentau, Anna Katharina Simon, Johanna Pott, Kevin J Maloy
Published 2016-02-01

Contrasting impact of rural, versus urban, living on glucose metabolism and blood pressure in Uganda [version 2; peer review: 2 approved]

by Richard E. Sanya, Irene Andia Biraro, Margaret Nampijja, Christopher Zziwa, Carol Nanyunja, Denis Nsubuga, Samuel Kiwanuka, Josephine Tumusiime, Jacent Nassuuna, Bridgious Walusimbi, Stephen Cose, Ponsiano Ocama, Richard K. Grencis, Alison M. Elliott, Emily L. Webb
Published 2020-08-01

Trichuris muris whey acidic protein induces type 2 protective immunity against whipworm.

by Neima Briggs, Junfei Wei, Leroy Versteeg, Bin Zhan, Brian Keegan, Ashish Damania, Jeroen Pollet, Kelly S Hayes, Coreen Beaumier, Christopher A Seid, Jamie Leong, Richard K Grencis, Maria Elena Bottazzi, K Jagannadha Sastry, Peter J Hotez
Published 2018-08-01

The major secreted protein of the whipworm parasite tethers to matrix and inhibits interleukin-13 function

by Allison J. Bancroft, Colin W. Levy, Thomas A. Jowitt, Kelly S. Hayes, Seona Thompson, Edward A. Mckenzie, Matthew D. Ball, Eamon Dubaissi, Aidan P. France, Bruno Bellina, Catherine Sharpe, Aleksandr Mironov, Sheila L. Brown, Peter C. Cook, Andrew S. MacDonald, David J. Thornton, Richard K. Grencis
Published 2019-05-01

Exclusive dependence of IL-10Rα signalling on intestinal microbiota homeostasis and control of whipworm infection.

by María A Duque-Correa, Natasha A Karp, Catherine McCarthy, Simon Forman, David Goulding, Geetha Sankaranarayanan, Timothy P Jenkins, Adam J Reid, Emma L Cambridge, Carmen Ballesteros Reviriego, Sanger Mouse Genetics Project, 3i consortium, Werner Müller, Cinzia Cantacessi, Gordon Dougan, Richard K Grencis, Matthew Berriman
Published 2019-01-01