A Memory of Early Life Physical Activity Is Retained in Bone Marrow of Male Rats Fed a High-Fat Diet

Studies have reported opposing effects of high-fat (HF) diet and mechanical stimulation on lineage commitment of the bone marrow stem cells. Yet, how bone marrow modulates its gene expression in response to the combined effects of mechanical loading and a HF diet has not been addressed. We investiga...

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Bibliographic Details
Main Authors: Dharani M. Sontam, Mark H. Vickers, Elwyn C. Firth, Justin M. O'Sullivan
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-07-01
Series:Frontiers in Physiology
Subjects:
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2017.00476/full