Amlexanox and Forskolin Prevents Isoproterenol-Induced Cardiomyopathy by Subduing Cardiomyocyte Hypertrophy and Maladaptive Inflammatory Responses

Amlexanox and Forskolin Prevents Isoproterenol-Induced Cardiomyopathy by Subduing Cardiomyocyte Hypertrophy and Maladaptive Inflammatory Responses

Chronic catecholamine stress (CCS) induces the occurrence of cardiomyopathy—pathological cardiac hypertrophy (PCH), which is characterized by left ventricular systolic dysfunction (LVSD). Recently, mounting evidence has implicated myocardial inflammation in the exacerbation of pathological cardiac r...

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Bibliographic Details
Main Authors: Gabriel Komla Adzika, Hongjian Hou, Adebayo Oluwafemi Adekunle, Ruqayya Rizvi, Seyram Yao Adzraku, Kexue Li, Qi-Ming Deng, Richard Mprah, Marie Louise Ndzie Noah, Joseph Adu-Amankwaah, Jeremiah Ong’achwa Machuki, Wenkang Shang, Tongtong Ma, Stephane Koda, Xianluo Ma, Hong Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
chronic catecholamine stress
amlexanox
forskolin
GRK5
adenylyl cyclase
cAMP
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.719351/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.719351/full

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