An intrinsic cell cycle timer terminates limb bud outgrowth

The longstanding view of how proliferative outgrowth terminates following the patterning phase of limb development involves the breakdown of reciprocal extrinsic signalling between the distal mesenchyme and the overlying epithelium (e-m signalling). However, by grafting distal mesenchyme cells from...

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Bibliographic Details
Main Authors: Joseph Pickering, Constance A Rich, Holly Stainton, Cristina Aceituno, Kavitha Chinnaiya, Patricia Saiz-Lopez, Marian A Ros, Matthew Towers
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-09-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/37429