Proinsulin misfolding is an early event in the progression to type 2 diabetes

Proinsulin misfolding is an early event in the progression to type 2 diabetes

Biosynthesis of insulin – critical to metabolic homeostasis – begins with folding of the proinsulin precursor, including formation of three evolutionarily conserved intramolecular disulfide bonds. Remarkably, normal pancreatic islets contain a subset of proinsulin molecules bearing at least one free...

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Bibliographic Details
Main Authors: Anoop Arunagiri, Leena Haataja, Anita Pottekat, Fawnnie Pamenan, Soohyun Kim, Lori M Zeltser, Adrienne W Paton, James C Paton, Billy Tsai, Pamela Itkin-Ansari, Randal J Kaufman, Ming Liu, Peter Arvan
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-06-01
Series:eLife
Subjects:
mouse
endoplasmic reticulum
GRP78
disulfide bonds
prediabetes
protein trafficking
Online Access:https://elifesciences.org/articles/44532

Internet

https://elifesciences.org/articles/44532

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