Transient Production of Human β-Glucocerebrosidase With Mannosidic-Type N-Glycan Structure in Glycoengineered Nicotiana benthamiana Plants

Transient Production of Human β-Glucocerebrosidase With Mannosidic-Type N-Glycan Structure in Glycoengineered Nicotiana benthamiana Plants

Gaucher disease is an inherited lysosomal storage disorder caused by a deficiency of functional enzyme β-glucocerebrosidase (GCase). Recombinant GCase has been used in enzyme replacement therapy to treat Gaucher disease. Importantly, the terminal mannose N-glycan structure is essential for the uptak...

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Bibliographic Details
Main Authors: Naphatsamon Uthailak, Hiroyuki Kajiura, Ryo Misaki, Kazuhito Fujiyama
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Plant Science
Subjects:
β-glucocerebrosidase
transient expression
Nicotiana benthamiana
N-glycosylation
plant-made pharmaceuticals
N-acetylglucosaminyltransferase I
Online Access:https://www.frontiersin.org/articles/10.3389/fpls.2021.683762/full

Internet

https://www.frontiersin.org/articles/10.3389/fpls.2021.683762/full

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